GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs56159542 | 1 | rs56159542 | chr19:19682971 | YJEFN3 | chr19:19639720-19648393:+ | 0.23 | 5.38 | 1.15E-7 | Attention deficit hyperactivity disorder symptom score |
| THCA | cis | rs11185790 | 1 | rs56160723 | chr10:91373631 | FLJ37201 | chr10:91451057-91457685:- | -0.17 | -3.64 | 0.000301 | Metabolic traits |
| THCA | cis | rs60843830 | 1 | rs56167434 | chr2:282137 | SH3YL1 | chr2:218138-264810:- | -0.94 | -25.62 | 9.65E-92 | Spherical equivalent (joint main effects and education interaction) |
| THCA | cis | rs2416257 | 1 | rs56167534 | chr5:110431551 | TSLP | chr5:110405778-110413722:+ | -0.34 | -4.41 | 1.25E-5 | Eosinophil counts |
| THCA | cis | rs2416257 | 1 | rs56167534 | chr5:110431551 | WDR36 | chr5:110427870-110466201:+ | 0.2 | 3.71 | 0.000234 | Eosinophil counts |
| THCA | cis | rs7742824 | 1 | rs56168551 | chr6:44104306 | TMEM63B | chr6:44095376-44123255:+ | 0.15 | 3.46 | 0.000599 | Major depressive disorder |
| THCA | cis | rs12143789 | 1 | rs56184857 | chr1:119468861 | WARS2 | chr1:119573841-119683295:- | 0.26 | 3.49 | 0.000532 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs9815354 | 1 | rs56207540 | chr3:41976627 | ULK4 | chr3:41288091-42003660:- | 1.07 | 15.39 | 1.05E-43 | Diastolic blood pressure |
| THCA | cis | rs8030605 | 1 | rs56215018 | chr15:56526648 | MNS1 | chr15:56720929-56757335:- | -0.24 | -3.51 | 0.000485 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs8030605 | 1 | rs56215018 | chr15:56526648 | TEX9 | chr15:56657644-56738071:+ | -0.34 | -5.81 | 1.12E-8 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs7112513 | 1 | rs562179 | chr11:116805204 | PCSK7 | chr11:117075789-117102811:- | -0.28 | -4.96 | 9.75E-7 | Protein quantitative trait loci |
| THCA | cis | rs1010254 | 1 | rs56221251 | chr5:151733019 | NMUR2 | chr5:151771102-151784840:- | -0.51 | -9.44 | 1.62E-19 | Optic nerve measurement (cup area) |
| THCA | cis | rs3771570 | 1 | rs56222556 | chr2:242364119 | ANO7 | chr2:242127924-242164791:+ | 0.32 | 3.8 | 0.000164 | Prostate cancer |
| THCA | cis | rs3771570 | 1 | rs56222556 | chr2:242364119 | SEPT2 | chr2:242254723-242293439:+ | -0.31 | -4.57 | 6.31E-6 | Prostate cancer |
| THCA | cis | rs4853036 | 1 | rs56223710 | chr2:70049715 | SNRNP27 | chr2:70121090-70132348:+ | 0.15 | 3.54 | 0.000434 | Colorectal or endometrial cancer |